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Dr. Timothy Lee Kam Yiu , Senior Consultant Neurosurgeon

Medical Group: The Brain and Spine Clinic
Qualification: F.A.M.S., M.B.B.S., F.R.C.S, F.R.C.S (Edinburgh)
Specialty: Neurosurgery
Medical Group Address: Gleneagles Hospital, Annexe Block #03-38, 6A Napier Road
Singapore 258500
Operating Hours: 9.00 am – 5.00 pm (Mon-Fri) 9.00 am - 1.00 pm (Sat)
Years of Practise: 30
Practice Locations: Gleneagles Hospital

Special interest in:
brain tumour
stroke problems
spine problems
low back pain
neck problems
pediatric tumours

Senior Consultant Neurosurgeon, Gleneagles Hospital, Mount Elizabeth Hospital,
Senior Visiting Consultant, John Hopkins Hospital
Co-ordinator, Mount Alvernia Brain Centre
Former Head, Divisaion of Neurosurgery, NUH
Former Director and Visting Consultant
Vascular Programe, National Neuroscience Institute
Former Assoc Professor, National University of Singapore

Dr Lee is Senior Consultant Neurosurgeon at Mount Elizabeth Hospital, Gleneagles Hospital and Mount Alvernia Hospital as well as Senior Visiting Consultant at John Hopkins Hospital (Singapore), a branch of the John Hopkins Hospital in the U.S.A. which specializes in cancer treatment. He is currently Co-ordinator of the Mount Alvernia Brain Centre, a Catholic hospital and was formerly Director of the Vascular Programmme at National Neuroscience Institute. He was the Head of Neurosurgerical Division, National University Hospital from 1990-2002 and was Associate Professor at the National University of Singapore for many years.

He was born in Hong Kong in 1957. At the age of 18, he went to Australia to study and matriculated with 6 A's including 4 special distinctions. He graduated with honours in both medicine and surgery from the University of Melbourne in 1981. He did his general surgical training in Singapore and obtained his FRCS (Edinburgh) in 1986 and joined National University of Singapore as faculty staff in 1987. From 1987-1990 he was sent to Oxford for neurosurgical training. Upon return to Singapore, he formed and headed the Division of Neurosurgery at the National University Hospital since 1990. He was the first Associate Professor in Neurosurgery of the university.

He has published more than 100 journal and conference papers, mostly in mostly international journals, including a first author publication in Lancet, one of the top medical journals in the world. He was a member of International Advisory Panel for World Congress of Minimal Invasive Neurosurgery. He has been invited to operate in Indonesia (Jakarta, Surabaya and Medan), Ho Chi Minh City, Shanghai and Christchurch, New Zealand. He has organized several workshops for training of younger neurosurgeons and received the "Star Award" and "Lend a Helping Hand" awards from NUH.

He has a special interest in brain tumour, stroke and spine problems, including low back pain and neck problems, pediatric tumours.

PUBLICATION
A. Novel ideas/ cutting edge technologies:

1. TKY Lee, J Latham, RSC Kerr, G Karr, PJT Teddy, P Anslow.
A new image transfer system - How does it affect the management of neurosurgical referrals.
Lancet 1990; 336 : 101-3.

2. YW Chia, TKY Lee, NW Kour, KH Tung, ES Tan.
Microchip implants on the sacral anterior roots in patients with spinal trauma : Does it improve bowel function?
Dis Colon Rectum 1995;8(4):48.

3. YW Chia, TKY Lee, NW Kour, KH Tung, ES Tan.
Microchip implants on the sacral anterior roots in patients with spinal trauma: Does it improve bowel function?
Dis Colon Rectum 1996;39:690-694

4. TKY Lee.
Electrical stimulation techniques to restore bladder function.
Neurosurgery Quarterly, an American referred journal 1997;7;4:264-272.
(Invited article)

5. CH Wang, K Sengothi and TKY Lee
Controlled release of human immunoglobulin G – I Release kinetics.
Journal of Pharmaceutical Sciences, Feb 1999;88;2:215-220

6. C H Wang, K Sengothi, H M Wong and TKY Lee
Controlled release of human immunoglobulin G II morphological characterization
Journal of Pharmaceutical Science, February 1999;88;2:221-228.

7. Kamalesh S, P C Tan, J J Wang, T K Y Lee, E T Kang and C H Wang,
Biocompatibility of electroactive polymers in tissues.
Journal of Biomedical Materials Research, 2000; 52: 467-478.

8. 35 F.J. Wang, T.K.Y. Lee and C.H. Wang , “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”,
Biomaterials, in press (2002).

B. PARKINSON’S DISEASE:

1. TKY Lee, Leong SK, Rauff A, Yue D, Po L, Wong P, Seifert W, Hitchcock E.
A bilateral Parkinson model in non-human primates by sequential intracarotid MPTP injection.
Journal of Restorative Neurology and Neurosciences 1992;4 (3):170

2. PTH Wong, WL Ting, TKY Lee.
A microdialysis study on striatal dopamine, 5-hydroxytryptamine and metabolites in conscious rats after various treatments. Evidence for extravesicular release of dopamine.
Neuroreport 1993;5;1:53-6

3. Watt F, TKY Lee, PSP Thong, SM Tang.
Nuclear microscopy in Parkinson's disease
Nuclear Instruments and Methods in Physics B 1995;104:361-4

4. Y He, PSP Thong, TKY Lee, PK Leong, CY Shi, PTH Wong, SY Yuan and F Watt.
Increased iron in the substantia nigra of 6-OHDA induced Parkinson rats: A nuclear microscopy study.
Brain Research, 1996:735:149-153.

5. PSP Thong, Y He, TKY Lee and F Watt
Nuclear microscopic investigation into the elemental change in the substantia nigra of unilateral MPTP lesioned Parkinsonian monkeys
Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms, 130;1997:460-466

6. Y He, TKY Lee and SK Leong
Effect of 6-OHDA injection on the AMPA glutamate receptor submits in the substantia nigra of Spragne-Dawley rats
Neuroscience Letters, 241;1998:1-4

7. Y He, TKY Lee and SK Leong
Time course and localisation of transferring receptor expression in the substantia nigra of 6-OHDA induced Parkinsonian rats
Neuroscience, 1999;91:579-585.

8. CW Ong, ZX Shen, Y He and TKY Lee
Raman microspectroscopy of the brain tissues in the substantia nigra and MPTP-induced Parkinson’s disease
Journal of Raman Spectroscopy, 1999;30:91-96

9. He, Yi, T K Y Lee and S K Leong,
Time course of dopaminergic cell death and changes in iron, ferritin and transferrin levels in the rat substantia nigra after 6-hydroxydopamine (6-OHDA) lesioning.
Free Radical Research, 1999; 31: 103-120. (United States).

10. He, Yi, T K Y Lee and S K Leong,
6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra.
Brain Research, 2000; 858, (1): 163-166.

11. Zhang Li, T K Y Lee, Y Wang and T W Soong,
Heterologous expression, functional characterization and localization of two isoforms of the monkey iron transporter Nramp2.
Biochemical Journal 2000; 1, 349(Pt 1): 289-297.

C. TUMOURS:

1. TKY Lee, Y Nakasu, MA Jefree, AJ Molyneux, CBT Adams.
Indolent glioma - A cause of epilepsy.
Archieves of Disease of Childhood 1989; 64: 1666-7.

2. TKY Lee, WS Lund, CBT Adams.
Factors influencing the preservation of the facial nerve during acoustic surgery.
British Journal of Neurosurgery 1990; 4: 5-8.

3. TKY Lee, BG Kenny, ER Hitchcock, PJ Teddy, H Palividas, W Harkness, CHA Meyer.
Supratentorial masses : Stereotactic or freehand biopsy.
Br J of Neurosurgy, 1991; 5: 331-8.

4. MA Jefree, AJ Molyneux, TKY Lee, CBT Adams.
Calvarial involvement in low grade intracerebral tumours presenting with epilepsy.
Clinical Radiology 1991; 44:406-9.

5. T C Ayi, HK Oh, TKY Lee, BFL Li.
A method for the simultaneous identification of human active and active-site alkylated 06-methylguarine-DNA methyltransferase and its possible application for monitoring human exposure to alkylating carcinogens.
Cancer Research 1994;54:3726-31.

6. CH Wang, J Li, CS Teo and TKY Lee
The delivery of BCNU to brain tumors
Journal of Controlled Release 1999; 61:21-41.(United States)


MISCELLANEOUS:

1. TKY Lee, RSC Kerr, CBT Adams.
Persistent CSF leucocytosis associated with intrathecal gentamycin.
Br J Neurosurgery 1989; 3: 517-20.

2. JS Compton, TKY Lee, NR Jones, G Waddell, PJ Teddy.
A double blind placebo controlled trial of the calcium blocking drug, nicardipine in the treatment of high doppler flow velocity following severe head injury.
British Journal of Neurosurgery 1990; 4: 9-16.

3. TKY Lee, FCT Voon, KW Chow, NH Teo.
Unusual variant of right paraduodenal hernia.
Australian and New Zealand Journal of Surgery 1990, 60(6): 483-5.

4. TKY Lee, W S Lund, CBT Adams.
Pasteurella multicodi - a rare cause of shunt infection.
British Journal of Neurosurgery 1990; 4: 237-8.

5. TKY Lee, PB Chacha, J Khoo.
The ossification of the posterior longitudinal ligament.
Surgical Neurology. 1991; 35 : 40-4.

6. TKY Lee, N Maynard, P Anslow, K McPherson, M Briggs, J Northona.
Post-myelogram headache - physiological or psychological ?
Neuroradiology 1991; 5;35:155-8.

7. HL Kong, BKC Ong, TKY Lee, JS Cheah.
Melioidosis of the brain presenting with a stroke syndrome.
Aust NE J Med 1993; 23;4:413-4

8. L Zhang, WY Ong and TKY Lee
Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections
Experimental Brain Research, 1999;126:509-516

9. Amrith, Shantha, Seang Mei Saw, T C Lim and T K Y Lee,
Ophthalmic involvement in cranio-facial trauma.
Journal of Cranio-Maxillo-Facial Surgery, 2000; 28: 140-147.

10. Ng, W H, Ning Chou and T K Y Lee, Giant aneurysms treated by bilateral
cervical carotid artery to proximal middle cerebral artery bypass and
balloon embolisation : A case report.
Journal of Clinical Neurosciences (2001) 8(6), 580-583.


LOCAL REFEREED JOURNALS

1. TKY Lee, ST Ho, J Khoo.
An unusual case of sacrococcygeal teratoma and a short review.
Annals of Academy of Medicine of Singapore 1985;14(4): 671-5.

2. TKY Lee, CH Low.
Routine retrogenography on 4,036 health screening patients in a private hospital out-patient clinic.
Singapore Medical Journal 1986;27(1): 18-25.

3. TS Vesagas, TKY Lee, G Baratham, J Kwan
Recovery from aphasia and conversion of handedness: a case report
Annals of Academy of Medicine of Singapore 1993;22(suppl):526-9.

4. BKC Ong, KO Lee, TKY Lee, PN Chong.
An index case of adrenomyeloneuropathy in a Chinese man.
Singapore Medical Journal 1994;35:643.

5. TKY Lee, R Chau, SK Leong.
The anatomy of the basal ganglia and Parkinson's disease : A review
Singapore Medical Journal 1995;36:74-6.